Novel Phenothiazine/Donepezil-like Hybrids Endowed with Antioxidant Activity for a Multi-Target Approach to the Therapy of Alzheimer s Disease
ANTIOXIDANTS, 11, 2022
Alessia Carocci , Alexia Barbarossa , Rosalba Leuci , Antonio Carrieri , Leonardo Brunetti , Antonio Laghezza , Marco Catto , Francesco Limongelli , Sílvia Chaves , Paolo Tortorella , Cosimo Damiano Altomare , M. Amélia Santos , Fulvio Loiodice , Luca Piemontese

Novel Rivastigmine Derivatives as Promising Multi-Target Compounds for Potential Treatment of Alzheimer s Disease
BIOMEDICINES, 10, 2022
David Vicente-Zurdo , Noelia Rosales-Conrado , M. Eugenia Leon-Gonzalez , Leonardo Brunetti , Luca Piemontese , M. Amélia Santos , Sandra M. Cardoso , Yolanda Madrid , Sílvia Chaves

Novel Donepezil-Arylsulfonamide Hybrids as Multitarget-Directed Ligands for Potential Treatment of Alzheimer s Disease
MOLECULES, 26, 3 2021
Fausto Queda , Sonia Calo , Karolina Gwizdala , Joao D. Magalhaes , Sandra M. Cardoso , Sílvia Chaves , Luca Piemontese , M. Amélia Santos

Derivatives of Tenuazonic Acid as Potential New Multi-Target Anti-Alzheimer s Disease Agents
BIOMOLECULES, 11, 1 2021
Viviana Poliseno , Sílvia Chaves , Leonardo Brunetti , Fulvio Loiodice , Antonio Carrieri , Antonio Laghezza , Paolo Tortorella , Joao D. Magalhaes , Sandra M. Cardoso , M. Amélia Santos , Luca Piemontese

Deep Eutectic Solvents as Effective Reaction Media for the Synthesis of 2-Hydroxyphenylbenzimidazole-Based Scaffolds en Route to Donepezil-Like Compounds
MOLECULES, 25, 2 2020
Luca Piemontese , Roberta Sergio , Federica Rinaldo , Leonardo Brunetti , Filippo Maria Perna , M. Amélia Santos , Vito Capriati

Novel tacrine-benzofuran hybrids as potential multi-target drug candidates for the treatment of Alzheimer s Disease
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 35, 211-226 1 2020
Gaia Fancellu , Karam Chand , Daniel Tomás , Elisabetta Orlandini , Luca Piemontese , Diana F. Silva , Sandra M. Cardoso , Sílvia Chaves , M. Amélia Santos

Design, Synthesis, and In Vitro Evaluation of Hydroxybenzimidazole-Donepezil Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer s Disease
MOLECULES, 25, 2 2020
Sílvia Chaves , Simonetta Resta , Federica Rinaldo , Marina Costa , Romane Josselin , Karolina Gwizdala , Luca Piemontese , Vito Capriati , M. Amélia Santos , Sandra M. Cardoso

An innovative approach for the treatment of Alzheimer s disease: the role of peroxisome proliferator-activated receptors and their ligands in development of alternative therapeutic interventions
NEURAL REGENERATION RESEARCH, 14, 43-45 1 2019
Luca Piemontese

New Approaches to Cancer Therapy: Combining Fatty Acid Amide Hydrolase (FAAH) Inhibition with Peroxisome Proliferator-Activated Receptors (PPARs) Activation
JOURNAL OF MEDICINAL CHEMISTRY, 62, 10995-11003 12 2019
Leonardo Brunetti , Fulvio Loiodice , Luca Piemontese , Paolo Tortorella , Antonio Laghezza

Hydroxypyridinone Derivatives: A Fascinating Class of Chelators with Therapeutic Applications - An Update
CURRENT MEDICINAL CHEMISTRY, 25, 97-112 2018
Sílvia Chaves , Luca Piemontese , Asha Hiremathad , Maria A. Santos

Exploring the chelating capacity of 2-hydroxyphenyl-benzimidazole based hybrids with multi-target ability as anti-Alzheimer s agents
NEW JOURNAL OF CHEMISTRY, 42, 16503-16515 10 2018
Sílvia Chaves , Asha Hiremathad , Daniel Tomás , Rangappa S. Keri , Luca Piemontese , M. Amélia Santos

Identification of the First PPAR alpha/gamma Dual Agonist Able To Bind to Canonical and Alternative Sites of PPAR gamma and To Inhibit Its Cdk5-Mediated Phosphorylation
JOURNAL OF MEDICINAL CHEMISTRY, 61, 8282-8298 9 2018
Antonio Laghezza , Luca Piemontese , Carmen Cerchia , Roberta Montanari , Davide Capelli , Marco Giudici , Maurizio Crestani , Paolo Tortorella , Franck Peiretti , Giorgio Pochetti , Antonio Lavecchia , Fulvio Loiodice

Donepezil structure-based hybrids as potential multifunctional anti-Alzheimer s drug candidates
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 33, 1212-1224 8 2018
Luca Piemontese , Daniel Tomás , Asha Hiremathad , Vito Capriati , Emanuel Candeias , Sandra M. Cardoso , Sílvia Chaves , M. Amélia Santos

New approaches for prevention and treatment of Alzheimer s disease: a fascinating challenge
NEURAL REGENERATION RESEARCH, 12, 405-406 3 2017
Luca Piemontese

Heterocyclic compounds as key structures for the interaction with old and new targets in Alzheimer s disease therapy
NEURAL REGENERATION RESEARCH, 12, 1256+ 8 2017
Asha Hiremathad , Luca Piemontese

New diphenylmethane derivatives as peroxisome proliferator-activated receptor alpha/gamma dual agonists endowed with anti-proliferative effects and mitochondrial activity
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 127, 379-397 2 2017
Luca Piemontese , Carmen Cerchia , Antonio Laghezza , Pamela Ziccardi , Sabina Sblano , Paolo Tortorella , Vito Iacobazzi , Vittoria Infantino , Paolo Convertini , Fabrizio Dal Piaz , Angelo Lupo , Vittorio Colantuoni , Antonio Lavecchia , Fulvio Loiodice

Deep Eutectic Solvents as Novel and Effective Extraction Media for Quantitative Determination of Ochratoxin A in Wheat and Derived Products
MOLECULES, 22, 1 2017
Luca Piemontese , Filippo Maria Perna , Antonio Logrieco , Vito Capriati , Michele Solfrizzo

Catechol-based matrix metalloproteinase inhibitors with additional antioxidative activity
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 31, 25-37 2016
Marilena Tauro , Antonio Laghezza , Fulvio Loiodice , Luca Piemontese , Alessia Caradonna , Davide Capelli , Roberta Montanari , Giorgio Pochetti , Antonella Di Pizio , Mariangela Agamennone , Cristina Campestre , Paolo Tortorella

Reduction of Aflatoxins in Apricot Kernels by Electronic and Manual Color Sorting
TOXINS, 8, 1 2016
Rosanna Zivoli , Lucia Gambacorta , Luca Piemontese , Michele Solfrizzo

Food Coloring Agents and Plant Food Supplements Derived from Vitis vinifera: A New Source of Human Exposure to Ochratoxin A
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 63, 3609-3614 4 2015
Michele Solfrizzo , Luca Piemontese , Lucia Gambacorta , Rosanna Zivoli , Francesco Longobardi